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Laboratory of Cell and Tissue Cultures
 

Laboratory of Cell and Tissue Cultures

Vyshgorodska street 67, Kyiv 04114, Ukraine
e-mail: labcellculture[a]gmail.com


Vitalii KYRYK -
Group Leader, Ph.D.
Galyna SKIBO - Principal Researcher, Professor, Ph.D.
Oleg TSUPYKOV  Senior Researcher, Ph.D. 
Alina USTYMENKO - Leading Researcher, Ph.D. 
Oksana RYBACHUK - Researcher, Ph.D.
Pavlo KLYMENKO - Junior Researcher, Ph.D. 
Konstyantyn KONDRATENKO -  Junior Researcher
Kateryna NIKOLSKA - Junior Researcher, PhD
Galyna SHMATKO - Technician

 

Main research directions

- study of neural stem cells at experimental ischemic stroke in mice in vivo. More...

study of regenerative potential of different type of stem cells at brain ischemia in vitro.  More...

- study of regenerative potential of adipose-derived stem cells at critical limb ischemia.

- study of regenerative potential of stem cells at heart ischemia.

Methods 

- multicolor cell phenotyping and sorting by flow cytometry. More...

- cell and tissue phenotyping using immunocyto- and immunohistochemistry.

- stem cell culture and directed differentiation. More...

- mouse embryo culture and micromanipulation. More... 

- modelling of ischemic injury of different tissue on laboratory mice.



Main publications

Articles

  • Yatsenko K, Lushnikova I Ustymenko A, Patseva M, Govbakh I, Kyryk V, Tsupykov O. Adipose-Derived Stem Cells Reduce Lipopolysaccharide-Induced Myelin Degradation and Neuroinflammatory Responses of Glial Cells in Mice. J. Pers. Med. 2020, 10(3), 66; https://doi.org/10.3390/jpm10030066
  • Ustymenko A, Kyryk V, Lutsenko T, Tsupykov O, Butenko G. Morphofunctional properties of adipose-derived multipotent mesenchymal stromal cells in vitro in ovariectomized mice of different ages. Cell and Organ Transplantology. 2019; 7(2):158-167. https://doi.org/10.22494/cot.v7i2.102
  • Lykhmus O, Kalashnyk O, Koval L, Voytenko L, Uspenska K, Komisarenko S, Deryabina O, Shuvalova N, Kordium V, Ustymenko A, Kyryk V, Skok M. Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors. Neuroscience. 2019; 413:31-44. https://doi.org/10.1016/j.neuroscience.2019.06.004 
  • V Shablii, M Kuchma, H Svitina, I Skrypkina, P Areshkov, V Kyryk, T Bukreieva, V Nikulina, Iu Shablii, G Lobyntseva. High Proliferative Placenta-Derived Multipotent Cells Express Cytokeratin 7 at Low Level. BioMed Research International. Volume 2019; Article ID 2098749, 13 pages. https://doi.org/10.1155/2019/2098749
  • Skok M., Lykhmus O., Koval L, Voytenko L., Uspenska K., Komisarenko S., Deryabina O., Shuvalova N., Kordium V., Ustymenko A., Kyryk V. Intravenously injected mesenchymal stem cells penetrate the brain and treat inflammation-induced brain damage and memory impairment in mice. Front. Pharmacol., 2019; 10:355.https://doi.org/10.3389/fphar.2019.00355 
  • O. O. Kalmukova, A. V. Yurchenko, V. M. Kyryk, V. M. Nepomnyaschy, O. M. Savchuk, and M. E. Dzerzhynsky. Effects of Melatonin Administration in Different Time Modes on Morphofunctional Indices of the Hypothalamic Serotonergic Neurons in Obese Rats. Neurophysiology, Vol. 50, No. 6, November, 2018.
  • Rybachuk, O., Kopach, O., Pivneva, T. and Kyryk, V. (2019). Isolation of Neural Stem Cells from the Embryonic Mouse Hippocampus for in vitro Growth or Engraftment into a Host Tissue. Bio-protocol 9(4): e3165. DOI: 10.21769/BioProtoc.3165.
  • Golovynska I, Kalmukova O, Svitina HM, Kyryk VM, Shablii VA, Senchylo NV, Ostrovska GV, Dzerzhinskyi M, Stepanov YV, Golovynskyi S, Ohulchanskyy TY, Liu L, Garmanchuk LV, Qu J. Morpho-Functional Characteristics of Bone Marrow Multipotent Mesenchymal Stromal Cells after Activation or Inhibition of Epidermal Growth Factor and Toll-Like Receptors or Treatment with DNA Intercalator Cisplatin. Cytometry Part A. 95A: 24–33, 2019. https://doi.org/10.1002/cyto.a.23593.
  • Kyryk V, Kuchuk O, Mamchur A, Ustymenko A, Lutsenko T, Tsupykov O, Yatsenko K, Skibo G, Bilko D, Bilko N. 3D culture of murine adipose-derived multipotent mesenchymal stromal cells in hydrogel based on carbomer 974P. Cell and Organ Transplantology. 2018; 6(2):195-201. https://doi.org/10.22494/cot.v6i2.91.
  • Svitina, H., Skrypkina, I., Areshkov, P., Kyryk, V., Bukreieva, T., Klymenko, P., Garmanchuk, L., Lobintseva, G., Shablii, V. Transplantation of placentaderived multipotent cells in rats with dimethylhydrazineinduced colon cancer decreases survival rate. Oncology Letters. 2018 (1899): 5034-5042.
  • Kopach O, Rybachuk O, Krotov V, Kyryk V, Voitenko N, Pivneva T. Maturation of neural stem cells and integration into hippocampal circuits: functional study in post-ischemia in situ.
  • Tsupykov O., Lushnikova I., Ustymenko A., Kyryk V., Nikandrova Y., Patseva M., Yatsenko K., Butenko G., Skibo G. The effects of multipotent mesenchymal stromal cells on mouse brain slices at their co-culture in an in vitro model of periventricular leukomalacia. Fiziologichnyi Zhurnal. 2017; 63(5):3-12
  • Tornero D., Tsupykov O., Granmo M., Rodriguez C., Grønning-Hansen M., Thelin J., Smozhanik E., Laterza C., Wattananit S., Ge R., Tatarishvili J., Grealish S., Brüstle O., Skibo G., Parmar M., Schouenborg J., Lindvall O., Kokaia Z. Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli. Brain. 2017; 140(3):692-706
  • Kanemitsu M., Tsupykov O., Potter G., Boitard M., Salmon P., Zgraggen E., Gascon E.,  Skibo G, Dayer A.G.,  Kiss J.Z. EMMPRIN overexpression in SVZ neural progenitor cells increases their migration towards ischemic cortex. Experimental Neurology. 2017; 7(3):457-463
  • Rybachuk O.A., Lazarenko Y.A., Krotov V.V., Voitenko N.V. Structural/Functional Characteristics of Organotypic Spinal Cord Slices under Conditions of Long-Lasting Culturing. Neurophysiology. 2017; 49(2):162-164
  • Kalmukova OO, Ustymenko AM, Lutsenko TM, Klymenko PP, Kyryk VM. Morphological and functional characteristics of cell culture derived from the mouse nail unit. Cell and Organ Transplantology. 2017; 5(1):62-66. doi:10.22494/cot.v5i1.69.
  • Tsupykov OM, Lushnikova IV, Ustymenko AM, Kyryk VM, Nikandrova YA, Patseva MA, Yatsenko KV, Butenko GM, Skibo GG. Protective effects of adipose-derived multipotent mesenchymal stromal cells of mice on periventricular leukomalacia model in vitro. Cell and Organ Transplantology. 2017; 5(1):28-32. https://doi.org/10.22494/cot.v5i1.66.
  • Svitina, H., Kyryk, V., Skrypkina, І., Kuchma, M., Bukreieva, T., Areshkov, P., Shablii, Y., Denis, Y., Klymenko, P., Garmanchuk, L., Ostapchenko, L., Lobintseva, G., Shablii, V. Placentaderived multipotent cells have no effect on the size and number of DMH-induced colon tumors in rats. Experimental and Therapeutic Medicine. 2017; 14 (3): 2135-2147.  https://doi.org/10.3892/etm.2017.4792
  • Kalmykova OO. Stem cells in nail unit of mammalians. Cell and Organ Transplantology. 2016; 4(1):138-143.
  • Shablii V, Kuchma M, Svitina H, Skrypkina I, Areshkov P, Kyryk V, Shablii Yu, Klymenko P, Lukash L, Lobintseva G. Placenta-derived multipotent cells shared the expression of several trophoblast-related genes. Placenta. 2016; 45:128.
  • Tsupykov O., Kanemitsu M., Smozhanik E., Skibo G., Dayer A.G., Kiss J.Z. Relationship of Grafted FGF-2 Overexpressing Neural Stem/Progenitor Cells with the Vasculature in the Cerebral Cortex. Cell Transplant. 2016; 25(7):1359-69.
  • Kopach O, Maistrenko A, Lushnikova I, Belan P, Skibo G, Voitenko N. HIF-1α-mediated upregulation of SERCA2b: The endogenous mechanism for alleviating the ischemia-induced intracellular Ca(2+) store dysfunction in CA1 and CA3 hippocampal neurons. Cell Calcium. 2016;59(5):251-61.
  • Svitina H, Kalmukova O, Shelest D, Skachkova O, Garmanchuk L, Shablii V. Cellular immune response in rats with 1,2-dimethylhydrazineinduced colon cancer after transplantation of placentaderived multipotent cells. Cell and Organ Transplantology. 2016; 4(1):55-60.
  • Tsupykov O, Lushnikova I, Nikandrova E, Yatsenko K, Ustymenko A, Kyryk V, Butenko G, Skibo G. Моделювання перивентрикулярної лейкомаляції на органотиповій культурі зрізів головного мозку миші. Cell and Organ Transplantology. 2016; 4(2):188-193. https://doi.org/10.22494/COT.V4I2.60
  • Lutsenko TM. Fetal microchimerism and prenatal diagnosis of genetic disorders. Cell and Organ Transplantology. 2016; 4(1):125-131.
  • Tsupykov O., Ustymenko A., Kyryk V., Smozhanik E., Yatsenko K., Butenko G., Skibo G. Ultrastructural study of mouse adipose-derived stromal cells induced towards osteogenic direction. Microsc Res Tech. 2016; 79 (6), 557-564. https://doi.org/10.1002/jemt.22670.
  • Ustymenko AM. Cell technologies in treatment of human intervertebral disc hernia: perspectives. Cell and organ transplantology. 2015; 3(2):202-207.
  • Rybachuk О. А., Кyryk V. М., Poberezhnyi P. A., Butenko G. M., Pivneva Т. А. Plasticity of bone marrow-derived stroma cells at grafting onto neural tissue after ischemic injury in vitro. Genes&Cells. 2015; 10(1):51-61.
  • Tsupykov O. M., Kyryk V. M., Ustymenko A. M., Yatsenko K. V., Butenko G. M., Skybo G. G. Effect of transplantation of adipose-derived multipotent mesenchymal stromal cells on the nervous tissue and behavioral responses in a mouse model of periventricular leukomalacia. Cell and organ transplantology. 2015; 3(1):68-73.
  • Maria D. Kuchma, Vitaliy M. Kyryk, Hanna M. Svitina, Yulia M. Shablii, Lubov L. Lukash, Galina S. Lobyntseva, Volodymyr A. Shablii Comparative analysis of the hematopoietic progenitor cells from placenta, cord blood, and fetal liver, based on their immunophenotype BioMed Research International, vol. 2015, Article ID 418752, 16 pages, 2015. https://doi.org/10.1155/2015/418752.  
  • Tsupykov O. Ultrastructural analysis of murine hippocampal neural progenitor cells in culture. Microscopy Research and Technique. 2015; 78(2):128-133.
  • Kyryk V.M. Multiparametric phenotyping and sorting of murine bone marrow haematopoietic stem cells subpopulations by flow cytometry. Biotechnologia Acta, 2014, vol. 7, No 6, pp. 51-56.
  • Mamchur AA. Possibilities for involvement of transformed multipotent mesenchymal stem cell in sarcomogenesis as tumor-initiating cells. Cell and organ transplantology. 2014; 2(2):22-25.
  • Kyryk V. M. Short-term migration of transplanted Lin-Sca-1+c-kit+ hematopoietic stem cells after hippocampal ischemic injury of mice. Cell and organ transplantology, 2014. Vol. 2, № 2, pp. 148-150.
  • Tsupykov ОМ. A protocol for isolation of fetal neural progenitor cells from mouse hippocampus. Cell and organ transplantology. 2014; 2(2):45-47.
  • Rybachuk O. A., Pivneva T. A. Contribution of neural stem cells to regeneration of the central nervous system. International Journal of Physiology and Pathophysiology, - 2014, Vol. 5, №1, pp. 83-96.
  • Tsupykov O. M., Kyryk V. M., Mamchur A. A., Poberezhnyi P. A., Butenko G. M., Skibo G. G. Transplantation of neural progenitor cells stimulates endogenous neurogenesis in mice after ischemic stroke. Cell and organ transplantology. 2014; 2(1):85-89.
  • Rybachuk O. A., Kyryk V. M, Poberezhnyi P. A., Butenko G. M., Skibo G. G., Pivneva T. A. Effect of bone marrow multipotent mesenchymal stromal cells on the neural tissue after ischemic injury in vitro. Cell and organ transplantology. 2014, 2, № 1, p. 74-78.
  • O. Tsupykov, V. Kyryk, E. Smozhanik, O. Rybachuk, G. Butenko, T. Pivneva and G. Skibo Long-term fate of grafted hippocampal neural progenitor cells following ischemic injury. Journal of Neuroscience Research 04/2014; https://doi.org/10.1002/jnr.23386.
  • V. A. Shablii, M. D. Kuchma, V. M. Kyryk, H. M. Svitina, Yu. M. Shablii, L. L. Lukash, G. S. Lobintseva. Mesenchymal and trophoblast immunophenotype of multipotent stromal cells from human placenta. Biopolymers and Cell. 2014. Vol. 30. N 2. P. 118-121.
  • Rybachuk O. A., Pivneva T. A. Prospects of the Use of Mesenchymal and Neuromesenchymal Stem Cells. Neurophisioligy. - 2013, Vol. 45, Issue 5-6, pp. 477-494.
  • Kuchma, M.; Shablii, V.; Kyryk, V.; Onishchenko, A.; Lukash, L.; Lobintseva, G. Comparative phenotypic analysis of populations of hemotopoietic progenitor cells with different expression level of CD34 derived from placental tissue and umbilical cord blood. Bulletin of Taras Shevchenko National University of Kyiv. Vestn; 2013, 64(2):p18.
  • Rybachuk О. А, Levin R. E., Кyryk V. М., Susarova D. K., Tsupykov О. M., Smozhanik E. G., Butenko G. M., Skibo G. G., Troshin P. A., Pivneva Т. А. Effect of a water soluble derivative of fullerene C60 on the features neural progenitor cells in vitro. Cell and organ transplantology. 2013; 1(1):102-107. 
  • Kuchma M., Shablii V., Kyryk V., Onishchenko A., Shablii Yu., Lukash L., Lobintseva G. Phenotypic heterogenecity of hematopoietic progenitor cells from placental tissue: comarative analysis with umbilical cord blood and fetal liver. Cell and organ transplantology. 2013; 1(1):70-73. 
  • Tsupykov O. M., Kyryk V. M., Rybachuk O. A., Poberezhnyi P. A., Mamchur A. A., Butenko H. M., Pivneva T. A., Skybo G. G. Effect of neural stem cell transplantation on cognitive functions of mice after cerebral ischemia-reperfusion. Cell and organ transplantology. 2013; 1(1):92-95. 
  • V.A. Shablii, M.D. Kuchma, V.M. Kyryk, G.S. Lobyntseva Preservation of parenchymal and stromal progenitors in cryopreserved human fetal liver. Cytology and Genetics. 2012; 46(1):41-46.
  • O.M. Tsupykov, A.O. Poddubna, K.G. Smozhanyk, V.M. Kyryk, O.V. Kuchuk, G.M. Butenko, E. Semenova, T.A. Pivneva, G.G. Skibo Integration of grafted neural progenitor cells in the host hippocampal circuitry after ischemic injury. Neurophysiology. 2011; 43(4):372-375.
  • O.M. Tsupykov, T. A. Pivneva, A.O. Poddubna, V.M. Kyryk, O.V. Kuchuk, G.M. Butenko, G.G. Skibo Migration and Differentiation of Fetal Neural Progenitor Cells in the Brain of Ischemic Animals. Int.J.Phys.Pathophys. 2010; 1(40):25-34.

 

Conference abstracts

  • V. Nikulina, M. Kuchma, T. Bukreieva, I. Zahanich, V. Kyryk, G. Lobintseva, V. Shablii, Cryopreservation of placenta tissue allows isolating viable mesenchymal and hematopoietic stem cells, Cytotherapy, 2019. 21 (5), S78-S79
  • Kalmukova OO, Yurchenko AV, Kyryk VM. Central serotonin and tryptophan levels in rats with diet-induced obesity at the different time of melatonin administration. Ukr. Biochem. J., 2018; 90(3):116.
  • O. Kalmykova, V. Kyryk, M. Dzerzhinsky Morpho-functional state of serotoninergic neurons of hypothalamus arcuate nucleus of rats with diet-induced obesity under different times of melatonin administration.  “Modern aspects of biochemistry and cell biology”, 05-06 October 2017 Dnipro, Ukraine
  • O. Kalmykova, O. Savchuk, M. Dzerzhinsky Melatonin improves skeletal muscles morphology and metabolism in high-calorie diet-induced obesity rat model. Third Kyiv Symposium “Smooth Muscle Physiology, Biophysiscs & Pharmacology: from genes and molecules to functions, disorders and their novel trearment opportunities”. 18-22 September 2017, Kyiv – Lutsk.
  • Pokholenko Ia., Toporova O., Rymar S., Shuvalova N., Ignatchenko P., Moshynets O., Kyryk V., Dubey I., Kordium V. The development of functionalized scaffold for extracellular matrix replacement therapy of chronic wounds. Cell and Organ Transplantology. 2017; 5(2):in press.
  • Kyryk VM. Advances in stem cells therapy for cardiovascular diseases. Cell and Organ Transplantology. 2017; 5(1):133. doi:10.22494/cot.v5i1.73.
  • Shablii V., Areshkov P., Bukreieva T., Skrypkina I., Nikulina V., Dotsenko V., Kyryk V., Lobintseva G. Placenta-derived multipotent cells express syncytin-1 and posses ability to fuse with trophoblast. Placenta. 2017; 57:254. http://dx.doi.org/10.1016/j.placenta.2017.07.109
  • Rybachuk OA, Arkhypchuk IV, Lazarenko YuA, Kyryk VM, Proshkina IO, Voitenko NV, Butenko GM. Development of the spinal cord injury model in mice. Cell and Organ Transplantology. 2017; 5(2): in press. doi:10.22494/cot.v5i2.80.
  • Rybachuk OA, Lazarenko YuA,  Medvedev VV, Kyryk VM, Yaminsky YuYa, Voitenko NV, Tsymbaliuk VI. Cultivation of murine bone marrow derived stromal cells with NeuroGelTM. Cell and Organ Transplantology. 2017; 5(2):in press. doi:10.22494/cot.v5i2.80.
  • Koval L., Deryabina O., Ruban T., Ustymenko A., Kyryk V., Skok M. Mesenchymal stem cells express nicotinic acetylcholine receptors. Abstract book of International Symposium on Cell Biology jointly with 5th Ukrainian Congress for Cell Biology, Odessa, 2016.
  • V Shablii, M Kuchma, H Svitina, I Skrypkina, P Areshkov, V Kyryk, Yu. Shablii, P. Klymenko, L. Lukash, G. Lobintseva Placenta-derived multipotent cells shared the expression of several trophoblast-related genes Placenta. 2016; 45:128.
  • O. Toporova, I. Pokholenko, N. Shuvalova, V. Kyryk, O. Deriabina, P. Morgunov, D. Irodov, V. Kordium Genetic engineering of mesenchymal stem cells from umbilical cord Wharton’s jelly. Meeting Abstracts World Conference on Regenerative Medicine 2015, Leipzig, Germany, October 21-23.10.2015. Regenerative Medicine, 2015 Vol. 10 No. 07s, p. 220.
  • O.K. Toporova, N.S. Shuvalova, V.M. Kyryk, S.M. Novikova, T.P., Ruban, P.V. Morgunov, Ia.O. Pokholenko, D.M. Irodov, V.A. Kordium Optimization of high-efficiency transfection of human mesenchymal stem cells with nanosized polyplexes. 3rd International research and practice conference Nanotechnology and Nanomaterials NANO-2015, August 26-29, 2015, Lviv:442.
  • T.M. Lutsenko, V.M. Kyryk, A.M. Ustimenko, P.P. Klimenko, G.D. Koval Lactobacillus as a therapeutic agent in the endometriosis treatment. Abstract book of the International Conference for Young Scientists, September, 21-25, 2015, Kyiv, p. 171.
  • V Shablii, H Svitina, M Kuchma, V Kyryk, I Skrypkina, P Areshkov Placental derived multipotent cells possess trophoblast specific features. Poster abstract book ISSCR 13th Annual Meeting, At Stockholm, Sweden, June 2015, P. 413.
  • Kuchma M., Kyryk V., Svitina H., Shablii Yu., Lukash L., Lobintseva G., Shablii V. Hematopoietic stem/progenitor cells from human placental tissue, umbilical cord blood, and fetal liver. Poster abstract book ISSCR 13th Annual Meeting, At Stockholm, Sweden, June 2015, P. 227.
  • H Svitina, Y Shablii, M Kuchma, V Kyryk, I Skrypkina, D Yevheniy, Transplantation of placental adherent multipotent cells does not affect mid/late tumor progression in dimethylhydrazine-induced colon carcinogenesis in rats. Poster abstract book ISSCR 13th Annual Meeting, At Stockholm, Sweden, June 2015, P. 17.
  • Tsupykov O., Kyryk V., Butenko H., Skibo G. Neural stem cells transplantation promote the spatial learning recovery after ischemic brain injury. Abstracts of the 1st International Symposium on Mechanisms Underlying Memory Storage and Pathological Learning Montpellier, May 19, 2015, Abstract book, P. 29.
  • O. Deryabina, N. Shuvalova, O. Toporova, I. Pokholenko, Y. Kasianenko, S. Verbovska, O. Pichkur, L. Pichkur, V. Kyryk, V. Kordium Combined cell-cytokine therapy for EAE treatment. ESGCT and NVGCT Collaborative Congress October 23-26, 2014. - Human Gene Therapy, 2014; 25 (11): A104.
  • H Svitina, V Shablii, M Kuchma, V Kyryk, Y Shablii, I Skrypkina, L Garmanchuk, G Kyznezova, O Dzhus, E Denis, V Zhezhera, V Rubalchenko, G Lobintseva Trophoblast stem cells: characteristics and anticancer properties // 3rd IPLASS Meeting, Spain, 10-12 September 2014 - p. 8.
  • V Shablii, M Kuchma, V Kyryk, H Svitina, Y Shablii, I Skrypkina, L Lukash, G Lobintseva Multipotent trophoblast cells derived from native and cryopreserved human placental tissue // 3rd IPLASS Meeting, Spain, 10-12 September 2014 - p. 7.
  • M Kuchma, V Shablii, V Kyryk, H Svitina, Y Shablii, L Lukash, G Lobyntseva Characteristics of hematopoietic stem/progenitor cells from placental tissue, umbilical cord blood and fetal liver // 3rd IPLASS Meeting, Spain, 10-12 September 2014. - p. 5.
  • - Shablii V., Kuchma M., Kyryk V., Onishchenko G., Tsupykov O., Klymenko P., Kuchuk O., Gabrielyan A., Domansky T., Onishchenko V., Lukash L., Lobyntseva G. Characteristics of multipotent mesenchymal stromal stem cells derived from native and cryopreserved human placental tissue // "Журнал НАМН України". — 2012. — т. 18, додаток. — с. 184-185.
  • Tsupykov O., Smozhanik E., Rybachuk O., Kyryk V., Kuchuk O., Patseva M., Butenko G., Skibo G., Pivneva T. Synapse formation between the grafted neural progenitor cells and host hippocampal neurons after ischemic injury // FENS Abstract, 2012, Volume 6, p048.25.
  • V. Shablii, M. Kuchma, V. Kyryk et al. Characteristics of hematopoietic and mesenchymal stem cells isolated from cryopreserved human placental tissue // ISSCR, 10th Annual Meeting, Yokohama, Japan, June 13-16, 2012. P. 95.
  • Volodymyr Shablii, Maria Kuchma, Vitaliy Kyryk, et al. Isolation and characterization of mutipotent mesenchymal stromal cells from native and cryopreserved human placental tissue // International Symposium on Cell Biology jointly with 3rd Ukrainian Congress for Cell Biology, Yalta, Ukraine, May 16 – 20, 2012. P.117.
  • Maria Kuchma, Volodymyr Shablii, Vitaliy Kyryk, et al. Isolation and characterization of hematopoietic stem cells from native and cryopreserved human placental tissue // International Symposium on Cell Biology jointly with 3rd Ukrainian Congress for Cell Biology, Yalta, Ukraine, May 16 – 20, 2012. P.118.
  • O. Kuchuk, O. Tsupykov, V. Kyryk Cultivation and osteogenic differentiation of murine bone marrow multipotent stromal cells in micromass culture // Abstracts of the DiSCUSS Meeting, December 5-8, 2011, Dresden, Germany. — P 43.
  • O. Deryabina, O. Maslova, O. Sukhorada, V. Kyryk, V. Kordium Diversity of umbilical cord MSC and their variability during passaging ex vivo // Abstracts of the World Conference on Regenerative Medicine, November 2-4, 2011, Leipzig, Germany. — Regenerative Medicine. — 2011. — vol. 6, № 6, Suppl. 2. — P. 196. 
  • O. Tsupykov, A. Poddubna, K. Smozhanyk, V. Kyryk, O. Kuchuk, T. Pivneva, G. Skibo, G. Butenko The grafted fetal neural progenitor cells can integrate in the adult hippocampal tissue after ischemic injury // Abstracts of the World Conference on Regenerative Medicine, November 2-4, 2011, Leipzig, Germany. — Regenerative Medicine. — 2011. — vol. 6, № 6, Suppl. 2. — P. 163. 
  • M. Kuchma, V. Shablii, V. Kyryk, A. Onishchenko, G. Lobitseva Cryopreserved human placental tissue as sourse of hematopoietis and mesenchymal stem cells // World Cord Blood Congress III "Cord blood transplantation and immunobiology of haematopoietic stem cell transplant", Rome, 27-29 October, 2011. – P 171.
  • V. Kyryk, O. Kuchuk, A. Rodnichenko, G. Butenko Proliferative activity of murine bone marrow cells after transplantation of mononuclear cells or sorted hematopoietic stem cells from bone marrow and fetal liver // World Cord Blood Congress III "Cord blood transplantation and immunobiology of haematopoietic stem cell transplant", Rome, 27-29 October, 2011. – P 172. 
  • O. Tsupykov, T. Pivneva, A. Poddubna, V. Kyryk, O. Kuchuk, G. Skibo Hippocampal-derived neural progenitor cells establish synaptic junctions after grafting into the adult ischemic brain // 8th IBRO World Congress of Neuroscience 2011 - Florence,  – D141.
  • Tsupykov O.M., Poddubna A.O., Smozhanyk K.G., Kyryk V.M., Kuchuk O.V., Butenko G.M., Semenova E., Pivneva T.A., Skibo G.G. The integration of grafted neural progenitor cells in the host hippocampal circuitry after ischemic injury // V Congress of the Ukrainian Society for Neurosciences - Kyiv, June 6-10, 2011. – P. 44.
  • Tsupykov O., Poddubna A., Ochenashko O., Petrenko A., Kyryk V., Kuchuk O., Butenko G., Skibo G., Pivneva T. Grafting of fetal neural progenitor cells into the adult ischemic brain / FENS Forum 2010, Amsterdam // FENS Abstr. - Vol.5, 016.31, 2010.
  • Kuchuk O., Vasyliev R., Kyryk V., Butenko G. Mesenchymal stem cells and mouse embryonic fibroblasts potential for directed differentiation and 3D-cultivation // 8th International Stem Cell School in Regenerative Medicine. Scientific conference - Stockholm, 3-5 Sept 2010. – P. 27.
  • Rodnichenko A., Kyryk V., Kuchuk O., Vasyliev R., Reznik O., Labunets I., Butenko G. The influence of stress on functional state of immune system and number of bone marrow haematopoietic stem cells and mesenchymal stromal cells of CBA/Ca and FVB mice // 8th International Stem Cell School in Regenerative Medicine. Scientific conference - Stockholm, 3-5 Sept 2010. – P. 53.
  • Tsupykov O., Skibo G., Pivneva T., Kyryk V., Kuchuk O., Butenko G. Neural progenitor cells transplantation at experimental ischemic brain injury // 8th International Stem Cell School in Regenerative Medicine. Scientific conference - Stockholm, 3-5 Sept 2010. – P. 29.
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